Cloning and characterization of an endogenous COS-7 cell thromboxane A2 receptor
نویسندگان
چکیده
منابع مشابه
Characterization of the Vascular Thromboxane A2 /Prostaglandin Endoperoxide Receptor
Recently, we have shown that dexamethasone treatment of rabbits specifically reduces vascular smooth muscle responsiveness to agonists that interact with the vascular thromboxane A2 / prostaglandin H2 (TXA2 / PGH2) receptor. One potential site at which dexamethasone can influence prostanoid-mediated vasoconstriction may be at the level of the vascular TXA2 IPGH2 receptor. Therefore, we characte...
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Background Aspirin, by nonselectively blocking cyclooxygenase both in platelets and in endothelial cells, not only inhibits the thromboxane A2 pathway of platelet activation but at the same time also the generation of vasodilating and platelet-inhibitory prostanoids, such as prostacyclin, by the endothelial cells. Ridogrel, by inhibiting thromboxane A2 synthase and blocking the thromboxane A2/p...
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Much work has recently focused upon the cellular involvement of the mesangium in glomerular inflammation and fibrosclerosis. A host of mediators of inflammation have been identified and their actions studied in mesangial cell cultures [1]. The recent identification of functional receptors for prostaglandins (PG) and thromboxane A2 (TxA2) in cultured glomerular mesangial cells [2, 3] has prompte...
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Thromboxane A2 receptors (TPs) are widely distributed among different organ systems and have been localized on both cell membranes and intracellular structures. Following the initial cloning of this receptor class from human placenta, the deduced amino acid sequence predicted seven-transmembrane spanning regions, four extracellular domains and four intracellular domains, making TP a member of t...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 1998
ISSN: 0167-4889
DOI: 10.1016/s0167-4889(98)00019-6